Drug Interactions With Herbs and Supplements

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ACE Inhibitors, See Antihypertensive Agents

Acetaminophen, See Analgesics

Acne preparations

Interactions with specific acne preparations:

Isotretinoin:

Vitamin A

Aids chemotherapeutic agents

Interactions with specific aids chemotherapeutic agents:

Non-nucleoside reverse transcriptase inhibitors:

St. John’s Wort

Protease inhibitors:

Garlic

St. John’s Wort

Analgesics

Interactions with specific analgesics:

Acetaminophen:

Vitamin C

Narcotic analgesics:

Cranberry

Nsaids:

Arginine

Dong Quai

Feverfew

Ipriflavone

St. John’s Wort

White Willow

Note: For NSAIDS (such as aspirin) that have strong antiplatelet effects, see also Antiplatelet Agents. For NSAIDs with photosensitizing effects (such as piroxicam), see also Photosensitizing Agents.

Angiotensin-Converting Enzyme (ACE) Inhibitors, See Antihypertensive Agents

Antacids (aluminum-containing)

Interactions with antacids (aluminum-containing) in general:

Calcium

Antiacne Agents, See Acne Preparations

Antianxiety Agents, See Sedatives

Antibiotics

Interactions with antibiotics in general:

Bromelain

Cranberry

Vitamin K

Interactions with specific antibiotics:

Erythromycin:

Red Yeast Rice

Fluoroquinolone antibiotics:

Calcium

Iron

Magnesium

Zinc

Nitrofurantoin:

Magnesium

Sulfonamides:

White Willow

Tetracycline antibiotics:

Calcium

Iron

Magnesium

Zinc

Note: For antibiotics with photosensitizing effects, see also Photosensitizing Agents.

Anticonvulsant agents

Interactions with anticonvulsant agents in general:

Glutamine

Interactions with specific anticonvulsant agents:

Carbamazepine:

Folate

Niacinamide

Primidone:

Niacinamide

Antidepressants

Interactions with specific antidepressants:

Mao inhibitors:

Interactions with mao inhibitors in general:

Ephedra

Green Tea

Interactions with specific mao inhibitors:

Phenelzine:

Ginseng

Tricyclic antidepressants:

Interactions with tricyclic antidepressants in general:

Yohimbe

Interactions with specific tricyclic antidepressants:

Antidiabetic agents

Interactions with specific antidiabetic agents:

Sulfonylureas:

Interactions with sulfonylureas in general:

Magnesium

Interactions with specific sulfonylureas:

Tolbutamide:

Ipriflavone

Antifungals

Interactions with specific antifungals:

Azole antifungals:

Red Yeast Rice

Antihypertensive agents

Interactions with antihypertensive agents in general:

Black Cohosh

Nettle

Yohimbe

Interactions with specific antihypertensive agents:

Ace inhibitors:

Interactions with ace inhibitors in general:

Arginine

Iron

Magnesium

Interactions with specific ace inhibitors:

Captopril:

Iron

Beta-blockers:

Calcium

Calcium channel blockers:

Interactions with calcium channel blockers in general:

Calcium

Vitamin D

Interactions with specific calcium channel blockers:

Methyldopa:

Iron

Nitroprusside:

Policosanol

Anti-insomnia Agents, See Sedatives

Antilipemic Agents, See Hypolipidemic Agents

Antimetabolites

Interactions with specific antimetabolites:

Methotrexate:

White Willow

Antimanic Agents, See Mood Stabilizers

Antimigraine Agents, See Serotonergic Agents

Anti-parkinsonian agents

Interactions with anti-parkinsonian agents in general:

Kava

Interactions with specific anti-parkinsonian agents:

Antiplatelet agents

Interactions with antiplatelet agents in general:

Bilberry

Bromelain

Chamomile

Devil’s Claw

Feverfew

Fish oil

Ginger

Ginkgo

Horse Chestnut Seed Extract

OPCs (Oligomeric Proanthocyanidin Complexes)

Oxerutins

PC-SPES

Policosanol

Quercetin

Red Clover

Vitamin E

White Willow

Note: For antiplatelet agents (such as aspirin) that have anti-inflammatory properties, see also NSAIDS.

Antipsychotic agents

Interactions with antipsychotic agents in general:

Cranberry

Phenylalanine

Interactions with specific antipsychotic agents:

Atypical antipsychotic agents:

Interactions with atypical antipsychotic agents in general:

St. John’s Wort

Interactions with specific atypical antipsychotic agents:

3clozapine:

Glycine

Phenothiazines:

Kava

Yohimbe

Antischizophrenics, See Antipsychotic Agents

Barbiturates, See Sedatives

Benzodiazepines, See Sedatives

Beta-Blockers, See Antihypertensive Agents

Bisphosphonates, See Bone Metabolism Regulators

Blood Modifiers, See Anticoagulants and Antiplatelet Agents

Bone metabolism regulators

Interactions with specific bone metabolism regulators:

Bisphosphonates:

Arginine

Bromocriptine, See Dopamine Agonists

Calcium Channel Blockers, See Antihypertensive Agents

Cancer chemotherapy agents

Interactions with cancer chemotherapy agents in general:

Lapacho

Vitamin C

Interactions with specific cancer chemotherapy agents:

Doxorubicin:

St. John’s Wort

Mitoxantrone:

St. John’s Wort

Cardiac glycosides (e.g., digoxin)

Interactions with cardiac glycosides (e.g., digoxin) in general:

Calcium

Eleutherococcus

Licorice

Magnesium

St. John’s Wort

Chelating agents

Interactions with specific chelating agents:

Penicillamine:

Iron

Magnesium

Zinc

CNS Depressants, See Sedatives

Cns stimulants

Interactions with cns stimulants in general:

Yohimbe

Coronary vasodilators (nitrates)

Interactions with coronary vasodilators (nitrates) in general:

N-Acetyl Cysteine

Corticosteroids

Interactions with corticosteroids in general:

Arginine

DHEA (Dehydroepiandrosterone)

Licorice

Cyclosporine, See Immunosuppressive Agents

Digitoxin, See Cardiac Glycosides

Digoxin, See Cardiac Glycosides

Diuretics

Interactions with specific diuretics:

Loop diuretics:

Licorice

Potassium-sparing diuretics:

Interactions with potassium-sparing diuretics in general:

Arginine

Magnesium

Licorice

Noni

White Willow

Interactions with specific potassium-sparing diuretics:

Amiloride:

Zinc

Thiazide diuretics:

Calcium

Licorice

Vitamin D

Dopamine agonists

Interactions with dopamine agonists in general:

Bugleweed

Chasteberry

Estrogens

Fibric Acid Derivatives, See Hypolipidemic Agents

Fungal Medications, See Antifungals

Glucocorticoids, See Corticosteroids

Gout preparations

Interactions with specific gout preparations:

Probenecid:

White Willow

H2-blocking agents

Interactions with h2-blocking agents in general:

Magnesium

Heparin, See Anticoagulant Agents

Hormonal Therapies, See Estrogens; Progesterone; and Thyroid Hormone

Hormone-Replacement Therapy, See Estrogens and Progesterone

Hydantoins, See Anticonvulsants

Hypnotics, See Sedatives

Hypoglycemic Agents, See Antidiabetic Agents

Hypolipidemic agents

Interactions with specific hypolipidemic agents:

Fibric acid derivatives:

Red Yeast Rice

Immunosuppressive agents

Interactions with immunosuppressive agents in general:

Aloe

Echinacea

Eleutherococcus

Ipriflavone

Thymus Extracts

Interactions with specific immunosuppressive agents:

Insomnia Medications, See Sedatives

Insulin, See Antidiabetic Agents

Loop Diuretics, See Diuretics

MAO Inhibitors, See Antidepressants

Metabolic Agents, See Thyroid Hormone

Methotrexate, See Antimetabolites

Migraine Medications, See Serotonergic Agents

Monoamine Oxidase Inhibitors, See Antidepressants

Mood stabilizers

Interactions with specific mood stabilizers:

Anticonvulsants

Interactions with anticonvulsants in general:

Glutamine

Interactions with specific anticonvulsants:

Carbamazepine:

Folate

Niacinamide

Primidone:

Niacinamide

Lithium:

Dandelion

Goldenrod

Any Herbal Diuretic

Narcotic Analgesics, See Analgesics

Nitrates, See Coronary Vasodilators

Nonsteroidal anti-inflammatory drugs (nsaids)

Interactions with nonsteroidal anti-inflammatory drugs (nsaids) in general:

Arginine

Dong Quai

Feverfew

Ipriflavone

St. John’s Wort

White Willow

Note: For NSAIDS (such as aspirin) that have strong antiplatelet effects, see also Antiplatelet Agents. For NSAIDs with photosensitizing effects (such as piroxicam), see also Photosensitizing Agents.

Opiates, See Analgesics

Oral contraceptives

Oral Hypoglycemic Agents, See Antidiabetic Agents

Osteoporosis Preparations, See Bone Metabolism Regulators

Pain Treatments, See Analgesics

Penicillamine, See Chelating Agents

Phenothiazines, See Antipsychotic Agents

Phenytoin, See Anticonvulsant Agents

Photosensitizing agents

Interactions with photosensitizing agents in general:

Dong Quai

St. John’s Wort

Platelet Inhibitors, See Antiplatelet Agents

Potassium-Sparing Diuretics, See Diuretics

Progesterone

Interactions with progesterone in general:

Chasteberry

Protease Inhibitors, See AIDS Chemotherapeutic Agents

Proton pump inhibitors

Interactions with proton pump inhibitors in general:

St. John’s wort

Sedatives

Interactions with sedatives in general:

Bromelain

Hops

Kava

Lemon Balm

Nettle

Passionflower

Valerian

Interactions with specific sedatives:

Alprazolam:

Kava

Selective Serotonin Reuptake Inhibitors (SSRIs), See Antidepressants

Serotonergic agents

Interactions with serotonergic agents in general:

5-HTP (5-Hydroxytryptophan)

St. John’s Wort

SAMe (S-Adenosylmethionine)

Sleep Aids, See Sedatives

SSRI Antidepressants, See Antidepressants

Statins, See Hypolipidemic Agents

Stimulants (CNS), See CNS stimulants

Theophylline

Interactions with theophylline in general:

Arginine

Cayenne

Ipriflavone

St. John’s Wort

Thiazide Diuretics, See Diuretic Agents

Thyroid hormone

Interactions with thyroid hormone in general:

Bugleweed

Calcium

Iron

Soy

Thyroid imaging

Interactions with thyroid imaging in general:

Bugleweed

Tranquilizers, See Antipsychotic Agents and Sedatives

Triptan Anti-migraine Agents, See Serotonergic Agents

Uricosuric Agents, See Gout Preparations

Vasodilators, See Coronary Vasodilators