Crouse Health Online: Wellness is just a click away.
Share Share
  |  Connect with Us: 
large
med
small
Text Size
 

Health News



Rotavirus Vaccine Trials Show Positive Results in Africa, Asia

Rotavirus Vaccine Trials Show Positive Results in Africa, Asia

08/06/10

FRIDAY, Aug. 6 (HealthDay News) -- Two new studies find that a vaccine against rotavirus is safe and effective in preventing severe rotavirus gastroenteritis (RVG), which is characterized by diarrhea, vomiting and fever, and causes the deaths of more than half a million children worldwide each year.

The researchers said their findings, published online Aug. 6 in The Lancet, support calls by international experts to make the vaccine available in Asia and Africa, where these two studies were conducted.

The first study included 2,036 infants, aged 4 to 12 weeks, in Bangladesh and Vietnam. The children were randomly selected to receive either three oral doses of Merck's pentavalent rotavirus vaccine (RotaTeq) or a placebo at six weeks, 10 weeks and 14 weeks of age.

At the end of the nearly two years of follow-up, there were 38 cases of severe RVG in the vaccine group, compared with 71 cases in the placebo group. That means the vaccine was 48 percent effective. Rates of serious side effects were 2.5 percent in the vaccine group and 2 percent in the placebo group, the investigators found.

"With a [World Health Organization] recommendation for rotavirus vaccines now in place, governments of developing countries in Africa and Asia are deciding how to prioritize introduction of rotavirus vaccine in their public health agendas," Dr. K. Zaman, of the International Center for Diarrheal Disease Research in Bangladesh, and colleagues wrote in their report.

"Our trial shows that a live oral rotavirus vaccine has the potential to halve the incidence of severe rotavirus gastroenteritis in developing populations in Asia. Alongside efficacy results for this vaccine in Africa, our study supports WHO's strong recommendation for expansion of rotavirus vaccine use to the poorest nations in Africa and Asia. Rotavirus vaccines have the potential to protect the lives of nearly 2 million children in the next decade alone," Zaman's team concluded.

The second study of 5,468 children aged 4 to 12 weeks in the African nations of Ghana, Kenya and Mali found that the vaccine was 39 percent effective over two years.

"The vaccine provided significant protection against severe rotavirus gastroenteritis in infants for nearly two years of follow-up. This protection was especially high through the first year of life (64.2 percent vaccine efficacy), when the disease burden, including mortality, is highest," wrote Dr. George E. Armah, of the University of Ghana, and colleagues.

"In Africa, where young children are dying from diarrheal disease and prompt medical care is often out of reach, the need to prevent rotavirus is especially urgent. Introduction of rotavirus vaccines for African children, along with imminent introduction of pneumococcal and meningococcal conjugate vaccines in parts of Africa, could instigate a new era of reduction of childhood disease and mortality," they concluded.

The studies were funded by the GAVI Alliance and Merck.

More information

The U.S. Centers for Disease Control and Prevention has more about rotavirus disease.

Copyright © 2010 HealthDay. All rights reserved.

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

OF INTEREST:
 

Latest News

Crouse Hospital First in Region to Use New da Vinci Xi Surgical System
more >

MedEx Bedside Prescription Delivery Service

Free service offers convenience, patient education at discharge.
more >

CrouseSports Express After-Hours Ortho Care

Immediate care of orthopedic injuries in kids and adults.
more >

Weight Loss Surgery

Is it right for you? Attend a free information seminar held twice monthly.
more >

Quality at Crouse

See how Crouse Hospital strives to provide the best in patient care.
more >

Cheer Up That Special Someone

Say get well or welcome a new arrival with a gift purchased right at Crouse.

more >

Make an Online Donation Now

Your donation of any amount helps support Crouse services & programs in a meaningful way.
more >

Shop Online Now

Say get well, thinking of you or welcome new baby with a unique gift from the Crouse Gift Shop.

more >