Statins May Guard Against Rheumatoid Arthritis09/08/10
WEDNESDAY, Sept. 8 (HealthDay News) -- Statins, lauded for their
ability to lower cholesterol and prevent heart attacks and strokes,
may also reduce the risk of developing rheumatoid arthritis,
Israeli researchers report.
"We found that statin users who purchased their medication persistently were less likely to develop rheumatoid arthritis over a long follow-up period," said lead researcher Gabriel Chodick, from Maccabi Healthcare Services in Tel Aviv.
For example, compared with patients who took statins less than
20 percent of the time, patients who took statins for 40 percent to
59 percent of the time had a 23 percent lower risk of developing
rheumatoid arthritis, he said.
"Patients who were covered for more than 80 percent of the time, had a 40 percent lower risk of developing rheumatoid arthritis," Chodick said. "The effect was stronger in younger patients and in patients using more effective statins."
The report was published online Sept. 7 in
For the study, Chodick's team collected data on 1.8 million
patients who got their health care through the Maccabi Healthcare
Services, an HMO in Israel.
The researchers looked for connections between statin use and
the development of both rheumatoid arthritis and osteoarthritis, a
degenerative joint disease that is unlikely to be affected by
statins, the researchers noted.
Over nine years of follow-up, 2,578 people developed rheumatoid
arthritis and 17,878 developed osteoarthritis.
When Chodick's group looked at statin use, they found that those
not taking statins had a 51 percent higher risk of developing
rheumatoid arthritis over about 80 percent of the follow-up
After looking for other possibilities, those who took statins
regularly had a 41 percent lower risk of developing rheumatoid
arthritis compared with people who were not taking statins
Among those taking statins, there was only a small, short-term
reduction in risk of development of osteoarthritis.
"Although the study does not have immediate clinical implications, our findings may suggest that patients who were prescribed statins and take it persistently may benefit from the many effects of statins, which go far beyond cholesterol reduction, including the reduction of rheumatoid arthritis risk," Chodick said.
A previous study on the same group indicated that persistent use
of statins was associated with substantially lower all-cause
mortality, which could not be explained only by the prevention of
cardiovascular disease, he said.
"We believe that a major part of the improved survival among statin users comes from the anti-inflammatory effects demonstrated by lower risk of rheumatoid arthritis. Unfortunately, our previous study indicated that, despite their benefits, many patients on statins discontinue their treatment," Chodick said.
This work received no outside or corporate finding, the
Dr. Robert Myerburg, a professor of medicine and physiology at
the University of Miami Miller School of Medicine, stressed that
"this is a study looking for an association, and it doesn't prove
that starting statins early in life will prevent or delay the onset
of rheumatoid arthritis."
The only way to prove the connection is with a clinical trial,
Myerburg said. "At this point, I would not use a statin for that
[prevention of rheumatoid arthritis] indication," he said.
For more information on statins, visit the
U.S. National Library of Medicine.
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