Fracture Risk Seen With Hormone Therapy for Prostate
TUESDAY, Nov. 9 (HealthDay News) -- Long-term use of androgen
deprivation therapy to treat prostate cancer may increase older
patients' risk of broken bones, according to a new study.
These findings suggest that careful consideration is needed
before doctors decide to use this therapy in older men with
localized disease, the researchers said.
They analyzed data from more than 46,500 men, aged 66 and older,
who survived at least five years after a diagnosis of localized
prostate cancer and received long-term androgen deprivation
Older men with co-existing health problems are usually
prescribed androgen deprivation therapy because they are not
suitable candidates for radiation therapy or surgery to remove the
But this study found that men treated with androgen deprivation
therapy had a 20 percent increased risk of a first fracture and a
57 percent increased risk of a second fracture after two years of
Older age, a higher number of co-existing health problems, and a
history of fracture and stroke were associated with increased risk
of fracture, the researchers said.
"Treating men who have pre-existing conditions with longer duration of androgen deprivation therapy exacerbates their risk of fracture, and becomes more pronounced over time," Grace Lu-Yao, a professor of medicine at the Cancer Institute of New Jersey and UMDNJ-Robert Wood Johnson Medical School, said in an American Association for Cancer Research (AACR) news release.
"Careful evaluation of the patient's risk of fracture, while initiating treatment, is important because fracture has a strong impact on quality of life and mortality," she added.
In addition, treatments involving removal of the testicles to
stop testosterone production (which prostate cancer needs in order
to grow) and/or long-term gonadotropin-releasing hormone use are
also associated with an increased risk of fracture among men with
The study findings were to be presented at the annual AACR
Cancer Prevention Research Conference, Nov. 7 to 10 in
The American Cancer Society has more about
androgen deprivation therapy.
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