Crouse Health Online: Wellness is just a click away.
Share Share
  |  Connect with Us: 
large
med
small
Text Size
 

Health News



Scientists Find Way to Boost 'Good' Cholesterol in Mice

Scientists Find Way to Boost 'Good' Cholesterol in Mice

11/16/10

TUESDAY, Nov. 16 (HealthDay News) -- New animal research has identified a sequence of genetic material that appears to stabilize levels of so-called "good" cholesterol, at least in mice.

Working with mice and primates, the study team found that the sequence in question -- labeled "miR-33a" -- helps to regulate cholesterol by serving as a kind of "off" switch for certain genes.

Specifically, the sequence was found to inhibit production of three proteins, thereby limiting the amount of circulating high-density lipoprotein (HDL) cholesterol found in the body.

In turn, if the sequence is "silenced," HDL levels go up, according to study co-authors Katey Rayner and Kathryn Moore, both of New York University Medical Center in New York City.

Rayner and Moore are slated to present their findings Tuesday in Chicago at the annual meeting of the American Heart Association.

Their observations are part of an effort to develop new treatments designed to elevate HDL levels.

Working with mice suffering from coronary artery disease, the researchers found that inhibiting the identified sequence prompted a 36 percent rise in HDL levels.

What's more, the effort also appeared to achieve some measure of reversal of atherosclerosis in the mice, with a reduction in lesions of 35 percent.

Both findings suggest that the sequence could prove to be an optimal target for the development of future HDL-raising drug therapies.

Experts note that research presented at meetings isn't subjected to the same type of scrutiny that research published in peer-reviewed journals undergoes. And research in animals often doesn't translate into success in human studies.

More information

For more on good cholesterol, visit the American Heart Association.

Copyright © 2010 HealthDay. All rights reserved.

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

OF INTEREST:
 

Latest News

Crouse Hospital Appoints Chief Information Officer
more >

MedEx Bedside Prescription Delivery Service

Free service offers convenience, patient education at discharge.
more >

CrouseSports Express After-Hours Ortho Care

Immediate care of orthopedic injuries in kids and adults.
more >

Weight Loss Surgery

Is it right for you? Attend a free information seminar held twice monthly.
more >

Quality at Crouse

See how Crouse Hospital strives to provide the best in patient care.
more >

Cheer Up That Special Someone

Say get well or welcome a new arrival with a gift purchased right at Crouse.

more >

Make an Online Donation Now

Your donation of any amount helps support Crouse services & programs in a meaningful way.
more >

Shop Online Now

Say get well, thinking of you or welcome new baby with a unique gift from the Crouse Gift Shop.

more >