Experimental Drug Raises Good Cholesterol Levels in Early
WEDNESDAY, Nov. 17 (HealthDay News) -- An experimental drug that
raises HDL, or "good," cholesterol seems to have passed an initial
hurdle by proving safe in preliminary trials.
Although the trial was primarily designed to look at safety,
researchers scheduled to present the finding Wednesday at the
American Heart Association's annual meeting in Chicago also report
that anacetrapib raised HDL cholesterol by 138 percent and cut LDL,
HDL's evil twin, almost in half.
"We saw very encouraging reductions in clinical events," said Dr. Christopher Cannon, lead author of the study, which also appears in the Nov. 18 issue of the New England Journal of Medicine.
A big study to confirm the results would take four to five years
to complete so the drug is still years away from market, said
Cannon, who is a cardiologist with Brigham and Women's Hospital in
Other experts are intrigued by the findings, but note that the
research is still in very early stages.
"There are a lot of people in the prevention/lipid field that are simultaneously excited and leery," said Dr. Howard Weintraub, clinical director of the Center for the Prevention of Cardiovascular Disease at NYU Langone Medical Center in New York City.
Added Dr. John C. LaRosa, president of the State University of
New York (SUNY) Downstate Medical Center in New York City: "It's
very preliminary but it's important because the last drug out of
the barrel of this type was not a success. This looks like a better
drug, but it's not definitive by any means. Don't take this to the
LaRosa was referring to torcetrapib, which, like anacetrapib,
belongs to the class of drugs known as cholesterol ester transfer
protein (CETP) inhibitors.
A large trial on torcetrapib was killed after investigators
found an increased risk of death and other cardiovascular
"I would be more excited [about anacetrapib] if I hadn't seen what happened to its cousin torcetrapib," Weintraub said. "Torcetrapib raised HDL astoundingly but that was entirely neutralized by the increase in cardiovascular events."
In the new trial, anacetrapib actually showed a tendency toward
fewer cardiovascular problems and fewer angioplasty or bypass
procedures, although the study only lasted 18 months.
It also didn't result in the blood pressure increases that
helped doom torcetrapib.
To assess the safety of the trial, investigators randomly chose
1,623 adults with coronary heart disease who were taking
cholesterol-lowering statins to receive either anacetrapib or a
placebo for 18 months.
At the end of six months, LDL cholesterol was cut 81 milligrams
per deciliter (mg/dl) of blood to 45 mg/dl, a reduction of about 40
percent. In the placebo group, LDL levels only declined from 82
mg/dl to 77 mg/dl.
Meanwhile, HDL levels increased from 41 mg/dl of blood to 101
mg/dl in the treatment arm, versus a small jump from 40 mg/dl to 46
mg/dl in the placebo group.
"We have 94 percent confidence that this drug doesn't have the harmful effect that torcetrapib had, but we didn't prove a reduction in events," said Brigham and Women's Cannon. "That will be the subject of a larger study."
Such a study is in the works, he added.
Dr. Neil Coplan, director of clinical cardiology at Lenox Hill
Hospital in New York City, stressed that this was a "safety trial,
not a trial which is saying in any way that people should take
these medications nor are the drugs approved."
Still, he added, "the trial demonstrated safety and it
demonstrated a tremendous effect on altering the lipid profile in a
good direction. It's very promising but, as the authors note
themselves, it's a first step."
Experts are still divided as to whether raising HDL levels will
actually result in any meaningful improvements in clinical
"Currently, we're not convinced that manipulation of HDL matters, though certainly it's promising," said Weintraub, who added that results should be available relatively soon from other trials exploring the issue. "The fact that LDL was also reduced also makes it promising."
"We've never been able to satisfactorily demonstrate that raising HDL actually changes risk," added LaRosa.
The only drug currently available to raise HDL is nyacin.
American Heart Association has more on
understanding your cholesterol levels.
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