Spleen Cells Tied to Damage of Spinal Cord Injury in
THURSDAY, Nov. 18 (HealthDay News) -- The spleen may be a major
source of cells that cause inflammation and exacerbate the damage
at the site of a spinal cord injury, a new animal study
The findings could change the focus of efforts to find new
treatments for spinal cord injuries, researchers said.
While most spinal cord injury research has focused on bone
marrow as the source of these inflammation-causing cells called
macrophages, some studies have suggested that another source may be
the spleen, which helps the body fight infections.
This study, conducted by researchers from Ohio State University,
compared two groups of mice with spinal cord injuries: mice that
had spleens and another group whose spleens were removed before the
injury. Two weeks after spinal cord injury, macrophage levels were
20 percent lower in the injured mice without spleens.
"The spleen is releasing cells that are traveling to the injury site, and it's a significant number of cells," study leader Alicia Hawthorne, a postdoctoral researcher in neuroscience at Ohio State University, said in a university news release.
"If we could target the spleen to decrease these cells or change their properties and make them less destructive, this might help promote the repair process as opposed to letting them cause inflammation or further damage to neurons," she added.
The study was presented at the recent annual meeting of the
Society for Neuroscience. Because it was presented at a medical
meeting, the data and conclusions should be viewed as preliminary
until published in a peer-reviewed journal.
The U.S. National Institute of Neurological Disorders and Stroke
has more about
spinal cord injuries.
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