Gene Tied to Inherited Form of Lou Gehrig's
THURSDAY, Dec. 9 (HealthDay News) -- A genetic mutation
associated with an inherited form of Lou Gehrig's disease -- known
in the medical world as amyotrophic lateral sclerosis (ALS) -- has
been identified by an international team of researchers.
About five percent of ALS cases are hereditary.
In their study, the team used a new type of genomics technology
called exome sequencing to find the mutation in the
valosin-containing protein (VCP) gene, which has been described as
a molecular "chaperone" aiding various cellular activities such as
"Identifying the genetic mutations responsible for the inherited form of ALS increases our knowledge of the disease process. Mutations in the VCP gene appear to cause one to two percent of the familial ALS cases," project leader Dr. Bryan Traynor, of the Laboratory of Neurogenetics at the U.S. National Institute on Aging, said in an NIA news release.
The study appears in the journal
ALS is a rapidly progressive, fatal neurological disease that
destroys the neurons that control voluntary muscles. People with
the disease lose their strength and the ability to move their arms,
legs and body. They eventually lose the ability to breathe.
The U.S. National Institute of Neurological Disorders and Stroke
has more about
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