Genetic Research Sheds Light on Adrenal Gland Tumor
TUESDAY, Dec. 14 (HealthDay News) -- Scientists report that they
have advanced their knowledge of genetic mutations associated with
adrenal gland tumors by identifying 13 new potential
Tumors called pheochromocytomas can affect the adrenal gland,
which is located above the kidney. These tumors -- which are
usually benign but can also be cancerous -- cause the adrenal gland
to produce too much adrenaline, resulting in high blood pressure,
headaches, heart palpitations, nausea and vomiting.
In the new study, which included nearly 1,000 people, the
researchers identified 19 mutations in the FP/TMEM127 gene that may
be associated with pheochromocytomas in the adrenal gland.
"Of these, 19 mutations found in 20 patients were considered of potential pathogenic significance. Thirteen of these variants were [new], while the remainder had been previously reported," Li Yao, of the University of Texas Health Science Center at San Antonio, and colleagues wrote in the report published in the Dec. 15 issue of the Journal of the American Medical Association.
The average age of patients when they developed
FP/TMEM127-mutated tumors was 42.8 years and median (midpoint) age
was 41.5 years.
"These observations support the existence of additional pheochromocytoma susceptibility genes, which may account for some of the genetically undefined cases," the authors wrote in a news release from the journal's publisher.
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