Crouse Health Online: Wellness is just a click away.
Share Share
  |  Connect with Us: 
large
med
small
Text Size
 

Health News



'Pathway' Leading to Health Declines of Aging Identified

'Pathway' Leading to Health Declines of Aging Identified

02/09/11

WEDNESDAY, Feb. 9 (HealthDay News) -- The "core pathway" that causes declining health due to aging has apparently been identified by researchers.

Studying mice in a laboratory setting, they found that malfunctioning telomeres are the basic cause of age-related health problems such as declining energy levels, metabolic disorders such as diabetes, and the failure of the heart and other organs.

Telomeres are the end-caps of chromosomes that protect against DNA damage. The telomeres become shortened and frayed as cells reach their pre-determined limit on the number of times they can divide. When this happens to telomeres, the ends of the chromosomes become vulnerable to increased rates of unrepaired DNA damage, explained the team at the Dana-Farber Cancer Institute in Boston.

The accumulation of damaged DNA causes cells to activate a gene called p53, which tells cells to either rest until the damage can be repaired or to self-destruct.

The study appears online Feb. 9 in the journal Nature.

"What we have found is the core pathway of aging connecting several age-related biological processes previously viewed as independent of each other," senior author Dr. Ronald A. DePinho said in a Dana-Farber news release.

This research was conducted in mice, but the "findings bear strong relevance to human aging as this core pathway can be directly linked to virtually all known genes involved in aging as well as current targeted therapies designed to mitigate the toll of aging on health," said DePinho, who is director of the Belfer Institute for Applied Cancer Science at Dana-Farber.

More information

The AGS Foundation for Health in Aging offers a guide for healthy aging.

Copyright © 2011 HealthDay. All rights reserved.

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

OF INTEREST:
 

Latest News

Crouse First in Area to Perform Single-Site Hysterectomy
more >

MedEx Bedside Prescription Delivery Service

Free service offers convenience, patient education at discharge.
more >

CrouseSports Express After-Hours Ortho Care

Immediate care of orthopedic injuries in kids and adults.
more >

Weight Loss Surgery

Is it right for you? Attend a free information seminar held twice monthly.
more >

Quality at Crouse

See how Crouse Hospital strives to provide the best in patient care.
more >

Cheer Up That Special Someone

Say get well or welcome a new arrival with a gift purchased right at Crouse.

more >

Make an Online Donation Now

Your donation of any amount helps support Crouse services & programs in a meaningful way.
more >

Shop Online Now

Say get well, thinking of you or welcome new baby with a unique gift from the Crouse Gift Shop.

more >