People With Bowel Disease at Higher Risk of Blood Clot in
TUESDAY, Feb. 22 (HealthDay News) -- People with inflammatory
bowel disease have double the risk of developing a potentially
deadly blood clot (venous thromboembolism) in the legs or lungs as
do people in the general public, a new study finds.
Inflammatory bowel disease includes Crohn's disease and
ulcerative colitis, both of which can cause abdominal pain,
vomiting, diarrhea, weight loss and other problems.
Venous thromboembolism (VTE) -- which includes deep vein
thrombosis, pulmonary embolism and superior sagittal sinus
thrombosis -- affects about two in every 1,000 people a year in the
United States and other developed nations.
Researchers compared the number of new cases of VTE diagnosed
between 1980 and 2007 in nearly 50,000 adults and children with IBD
and more than 477,000 members of the general public.
After they factored in known VTE risk factors such as a broken
bone, cancer, surgery and pregnancy, the researchers concluded that
people with IBD were two times more likely to develop VTE than
those in the general public.
In general, VTE is more common in older people, whether or not
they have inflammatory bowel disease. But this study found that the
risk of VTE in people with inflammatory bowel disease was highest
in younger age groups, compared with the general population.
In people aged 20 or younger, the risk of pulmonary embolism was
six times higher for those with IBD.
Even after adjusting for cardiovascular disease, diabetes,
congestive heart failure, hormone replacement therapy or
antipsychotic drugs, all of which are known to raise the likelihood
of VTE, the risk still remained up to 80 percent higher.
The findings, published online Feb. 21 in the journal
Gut, suggest that IBD may be an independent risk factor for clot formation, said the researchers.
The U.S. National Heart, Lung, and Blood Institute has more
deep vein thrombosis.
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