Microchip Spots Cancerous Tumors Within an Hour, Study
WEDNESDAY, Feb. 23 (HealthDay News) -- Scientists say they have
developed a microchip that can be attached to a smart phone and
diagnose cancerous tumors within an hour, from the patient's
The so-called microNMR chip, which uses magnetic nanoparticles
to measure proteins and other chemical compounds in tumors,
requires only tiny amounts of tissue to make a diagnosis,
researchers said. Instead of more invasive methods, the biopsy can
be done with fine needle aspiration, which withdraws cells from
"We tried to determine a molecular fingerprint, if you will," said study co-author Jered B. Haun, a postdoctoral researcher at Massachusetts General Hospital in Boston. "It was a nice surprise just how well it worked with all the protein markers. One of our big goals was not only to be able to tell patients they have cancer as accurately as possible, but as quickly as possible."
The study, which was funded by grants from the U.S. National
Institutes of Health, is published in the Feb. 23 issue of the
Science Translational Medicine.
Using the microchip -- which can be hooked up to smart phones
such as iPhones and Blackberrys -- researchers analyzed tissue
samples from 50 patients with suspected malignancies, correctly
diagnosing cancer in 44 patients within 60 minutes in 96 percent of
cases by zoning in on four of nine protein markers.
In contrast, standard pathology methods typically require three
or more days to produce a diagnosis and are only 84 percent
accurate, the researchers noted.
Study participants, whose average age was 64, had suspicious
lesions in a variety of organs, including the lungs, colon,
pancreas, liver and breasts, and were already scheduled to receive
biopsies for abnormal stomach tissue. Their results were validated
with traditional pathology -- which also didn't assess differences
in tumor cell types as well as the microchip -- along with an
independent group of 20 additional patients, Haun said. The
microchip diagnoses in the additional group were 100 percent
accurate, according to the study.
"False negatives and non-diagnostic samples are both at higher incidence with standard pathology," Huan said. "Since the [microchip-tested] sample size is so small, we take small aspirants of different areas of the tumor ... to get a more global view of the results," which can also impact treatment requirements.
Huan and the other study authors reported no financial conflicts
Dr. Moritz Kircher, a diagnostic radiologist at Memorial
Sloan-Kettering Cancer Center in New York City, said he envisions
the microchip eventually being used to diagnose an array of
malignancies, both internal and external.
"I see it more as a universal method because it relies on biological markers," said Kircher, also an assistant professor of radiology at Weill Cornell Medical College. "This is basically the first time they've used this in a clinical study and the results are very promising."
Haun and Kircher agreed more research would be needed before the
microchip technology could be used routinely and that greater
numbers of patients with more types of possible malignancies should
be studied. Haun said he also hopes the microchip will one day be
able to analyze blood samples to minimize invasive procedures.
Once marketed, the tool should be inexpensive to produce, Haun
noted, possibly only dollars per chip.
"Like cell phones in general, the more you make, the cheaper they get," he said. "It's not an expensive device at all."
With the data at hand, however, it should be easy to convince
potential investors to put the necessary cash into promoting the
technology, said Dr. Jan Grimm, a nanotechnology researcher and
radiologist at Memorial Sloan-Kettering Cancer Center.
"When they can claim a better result than [traditional diagnostic methods], that's pretty amazing," Grimm said. "It's better than pathology, which is considered the gold standard."
For more on cancer pathology, visit the
National Cancer Institute.
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