Low Vitamin D Levels Linked to More Aggressive Breast
FRIDAY, April 29 (HealthDay News) -- Breast cancer patients with
low levels of vitamin D have more aggressive tumors and poorer
outcomes, a new study finds.
Experts say the new findings support what many oncologists have
"There has been suspicion that vitamin D is related to breast health in some way, although the particular pathway is still unknown," noted Dr. Laurie Kirstein, a breast surgeon at Beth Israel Medical Center in New York City. "Many oncologists are already following vitamin D levels in their breast cancer patients, and recommending supplements for low levels," added Kirstein, who was not involved in the new study. "To link vitamin D levels to the aggressiveness of a particular type of breast cancer is an interesting finding; one that should be validated with a controlled trial."
In the study, to be presented Friday at the annual meeting of
the American Society of Breast Surgeons, a team from the University
of Rochester Medical Center (URMC) tracked 155 women who had
surgery for breast cancer between January 2009 and September
The team examined blood tests that provided vitamin D levels for
all the patients in the one-year period before and after surgery.
They also analyzed relevant patient breast cancer data, such as
age, race, cancer stage at diagnosis, menopause status, gene
expression, and estrogen and progesterone status.
The researchers found an association between low vitamin D
levels (less than 32 milligrams per milliliter of blood) and poor
scores on every major biological marker used to predict a breast
cancer patient's outcome.
"The magnitude of the findings was quite surprising," lead researcher Luke J. Peppone, research assistant professor of radiation oncology, said in a URMC news release. "Based on these results, doctors should strongly consider monitoring vitamin D levels among breast cancer patients and correcting them as needed."
Another expert said the findings do raise a red flag, but more
study may be needed.
"There appears to be increasing evidence linking vitamin D levels and breast cancer," said Dr. Sharon M. Rosenbaum Smith, a breast cancer surgeon at the Comprehensive Breast Center at St. Luke's-Roosevelt Medical Center in New York City. "This study certainly shows another link between the two. However, a direct cause and effect relationship has not been proven. This study certainly suggests that continued optimization of a patient's vitamin D level may be advantageous."
Vitamin D is found in certain foods, but humans synthesize most
of the nutrient they need via the action of sunlight on exposed
skin. Supplements can also boost levels of vitamin D.
The Rochester team said their study is one of the first to look
at the link between vitamin D levels and breast cancer progression.
Previous studies have concentrated on vitamin D deficiency and the
risk of cancer development only.
According to study leader Peppone, further research is required
to learn more about the biological basis of the association between
vitamin D and breast cancer outcomes, but this study shows the
importance of checking vitamin D levels in breast cancer
Experts note that research presented at meetings is considered
preliminary until it is published in a peer-reviewed journal.
The American Cancer Society has more about
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