Researchers Say They've Found Common Cause of All Types
SUNDAY, Aug. 21 (HealthDay News) -- The apparent discovery of a
common cause of all forms of amyotrophic lateral sclerosis (ALS)
could give a boost to efforts to find a treatment for the fatal
neurodegenerative disease, a new study contends.
Scientists have long struggled to identify the underlying
disease process of ALS (also known as Lou Gehrig's disease) and
weren't even sure that a common disease process was associated with
all forms of ALS.
In this new study, Northwestern University researchers said they
found that the basis of ALS is a malfunctioning protein recycling
system in the neurons of the brain and spinal cord. Efficient
recycling of the protein building blocks in the neurons are
critical for optimal functioning of the neurons. They become
severely damaged when they can't repair or maintain themselves.
This problem occurs in all three types of ALS: hereditary,
sporadic and ALS that targets the brain, the researchers said.
The discovery, published Aug. 21 in the journal
Nature, shows that all forms of ALS share an underlying cause and offers a common target for drug therapy, according to the researchers.
"This opens up a whole new field for finding an effective treatment for ALS," study senior author Dr. Teepu Siddique, of the Davee Department of Neurology and Clinical Neurosciences at Northwestern's Feinberg School of Medicine, said in a university news release. "We can now test for drugs that would regulate this protein pathway or optimize it, so it functions as it should in a normal state."
This finding about the breakdown of protein recycling in ALS may
also prove useful in the study of other neurodegenerative diseases,
specifically Alzheimer's and other dementias, the Northwestern
ALS afflicts an estimated 350,000 people around the world. About
50 percent of patients die within three years of the first
symptoms. They progressively lose muscle strength until they're
paralyzed and can't move, speak, swallow and breathe, the
The U.S. National Institute of Neurological Disorders and Stroke
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