Melanoma May Be More Aggressive in Kids10/07/11
FRIDAY, Oct. 7 (HealthDay News) -- Some children with melanoma
are more likely to have invasive disease than adults with this
potentially deadly type of skin cancer, a new study indicates.
The findings suggest that there may be biological differences
between childhood and adult melanoma, said the researchers at the
Johns Hopkins Children's Center in Baltimore.
They analyzed the medical records of 717 children and 1,368
young adults (aged 20 to 24) diagnosed with melanoma and compared
sentinel lymph node biopsy results based on tumor size, tumor
appearance and patient age. Sentinel lymph nodes are those that
surround the tumor, and sentinel lymph node biopsy is the standard
way to assess spread (metastasis) of the cancer and determine
Cancer cells were found in the sentinel lymph nodes of 25
percent of children and 14 percent of adults who had biopsies.
Tumor thickness was the strongest predictor of lymph node
metastases in both children and adults.
But children with tumors with a thickness of 1.01 and 2
millimeters were nearly six times more likely than young adults
with same-thickness tumors to have cancer cells in sentinel lymph
The researchers also found that children younger than 10 were
more likely to have distant metastases (spread of cancer beyond the
immediate tumor site) and greater tumor thickness, compared with
older children and young adults.
Regardless of age, patients with bleeding tumors or those with
open sores were more likely to have metastases.
The study was published online Oct. 5 in the journal
"Our finding is a powerful reminder that there's much about pediatric melanoma that we don't understand and that, just as is the case with other diseases, children are not small adults, but differ markedly in their response to disease," senior investigator Dr. John Strouse, a pediatric hematologist and oncologist, said in a Johns Hopkins Medicine news release.
Although still uncommon, melanoma diagnoses in children are
increasing, and unprotected sun exposure, sunburns and indoor
tanning are some of the known causes.
The American Academy of Family Physicians has more about
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