Preemies With Faster Brain Growth May End Up
WEDNESDAY, Oct. 12 (HealthDay News) -- Growth in a particular
part of a premature baby's brain in the first weeks and months
following birth may predict how well a youngster is able to think,
plan and pay attention later in childhood, new research
In a study published in the Oct. 12 issue of
Neurology, British researchers used MRI to measure the brains of 82 premature infants born before 30 weeks -- well ahead of the typical 40-plus weeks a normal pregnancy involves.
In the study, MRI measured an area of the brain called the
cerebral cortex, the outer layer of "gray matter" that looks like
deep folds and wrinkles, and which covers the cerebrum. It is
responsible for a variety of functions including memory, attention
and language. Scientists believe the winding outer covering's
structural complexity, also referred to as the "cortical ribbon" --
not just brain volume -- is a key to intelligence.
Brain images were taken during the early weeks and months that
followed the premature births -- the time frame during which the
babies would have been carried by the mother if born full-term.
Later, at age 2, and again at age 6, the children were given
intelligence and developmental tests.
The greater the cerebral cortex growth was in early life, the
better the child performed complex tasks at age 6, said study
author Dr. David Edwards, a professor of neonatal medicine and
director of the Centre for the Developing Brain at Imperial
College, in London.
"The period before normal-term delivery is critical for the growth of the brain in quite specific ways, and if this is disrupted by being born too early, it affects long-term cognitive abilities," Edwards explained.
Edwards said a 5 percent to 10 percent reduction in the surface
area of the cerebral cortex at full-term age predicted a lower
score on intelligence tests at age 6. However, he noted that a
child's motor skills were not linked with the rate of cerebral
cortex growth, and overall brain size was not connected to general
cognitive ability either.
The research has merits, said Dr. Peter Rosenberger, a
developmental neurologist who wrote an accompanying editorial.
"What the study helps confirm is that it is not the size of the brain that matters, but rather its complexity, which the authors have defined as number of folds or convolutions per unit of brain mass. What we don't know yet is what this greater complexity confers upon the brain," said Rosenberger, formerly director of the Learning Disorders Unit at Massachusetts General Hospital, currently in private practice in Boston.
Because there was no group of full-term babies to compare the
premature infants with, the study reveals little about brain
development in babies born early, said Rosenberger.
In his editorial, Rosenberger said the authors' frequent
references to "rate of growth" are somewhat misleading, and he
noted that nearly 30 percent of the infants were only scanned one
time, which doesn't allow for tracking a growth rate.
"The results are not a huge surprise," said Dr. Judy Bernbaum, medical director of the neonatal follow-up program at The Children's Hospital of Philadelphia. She agreed with Rosenberger's editorial: "It helps to confirm that the better developed your brain is early on, the more likely you're going to do better from a developmental standpoint later on."
Bernbaum said parents of preemies with lower brain volume
shouldn't worry, though. "Brain growth goes on for a couple of
years. Even if at birth you have low brain volume, you still have a
lot of potential you can maximize," she said.
Good nutrition in the first two years of life, a healthy and
low-stress home environment and stimulation from parents and
caretakers all contribute to the growth of the brain, Bernbaum
The study doesn't provide answers to how to boost your baby's
"For the public, they are always eager to know what can I do? But we don't really have a handle on it here. This is not a study demonstrating the effect of an intervention," said Raman Sankar, chief of pediatric neurology at Mattel Children's Hospital at the University of California, Los Angeles. But, Sankar said, "people with preemies can go to development centers and get a lot of therapy. It can't hurt and probably helps."
Building a healthy brain can begin well before birth, too,
Bernbaum added. Pregnant women who take a prenatal vitamin, eat a
well-balanced diet low in salt and fat, and rich in calcium and
protein, are giving their children, even babies born prematurely,
the best odds, Bernbaum said.
There's more on the care of premature babies at the
March of Dimes.
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