Links to Mental Illness Seen in Fetal Brains:
WEDNESDAY, Oct. 26 (HealthDay News) -- The genes suspected of
causing autism, schizophrenia and other mental illnesses are
activated in the developing brain before birth, according to a
major genetic analysis.
The study by researchers at Yale University also spotted
hundreds of genetic differences between males and females still in
"We knew many of the genes involved in the development of the brain, but now we know where and when they are functioning in the human brain," said study senior author Nenad Sestan, an associate professor of neurobiology and researcher for Yale's Kavli Institute for Neuroscience, in a university news release. "The complexity of the system shows why the human brain may be so susceptible to psychiatric disorders."
In conducting the study, researchers examined more than 1,300
tissue samples taken from 57 people at different stages of brain
development, ranging from 40 days after conception to 82 years.
They tracked thousands of human genes to determine which are
involved in development, where they are located and when they are
"expressed," or activated.
The study, published in the Oct. 27 issue of the journal
Nature, revealed a significant amount of the human brain is shaped before birth. For instance, the researchers found proof that genes linked to autism and schizophrenia are activated while in the womb.
"We found a distinct pattern of gene expression and variations prenatally in areas of the brain involving higher cognitive function," said Sestan in the news release. "It is clear that these disease-associated genes are developmentally regulated."
The study also found distinct differences before birth in many
genes shared by both sexes.
The U.S. National Institute of Mental Health provides more
information on the link between
genetics and mental illness.
Copyright © 2011
. All rights reserved.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.