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Erwinaze Approved for Acute Lymphoblastic Leukemia

Erwinaze Approved for Acute Lymphoblastic Leukemia

11/18/11

FRIDAY, Nov. 18 (HealthDay News) -- Erwinaze (asparaginase Erwinia chrysanthemi) has been approved by the U.S. Food and Drug Administration to treat Acute Lymphoblastic Leukemia (ALL) among people who have developed an allergy to more standard treatments.

In this type of cancer, bone marrow produces too many infection-fighting white blood cells called lymphocytes. Typically, treatments include asparaginase and pegaspargase chemotherapy drugs. But some patients develop allergies to these medications.

Newly approved Erwinaze, injected into a muscle three times weekly, breaks down a protein building block that helps overabundant white blood cells (leukemia cells) grow. Without this protein, the leukemia cells die, the FDA said in a news release.

The safety and effectiveness of Erwinaze were evaluated in clinical studies involving 58 people. Additional safety data was harvested from a separate trial involving 843 patients, the FDA said. Observed side effects of Erwinaze included severe allergic reactions, pancreatic inflammation, high liver enzymes, abnormal bleeding or clotting, nausea and high blood sugar.

Erwinaze has been designated an orphan drug, since ALL affects fewer than 200,000 people in the United States, the FDA said.

The drug is produced by EUSA Pharma Inc., based in Langhorne, Pa.

More information

Medline Plus has more about this form of cancer.

Copyright © 2011 HealthDay. All rights reserved.

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

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