CDC Issues New TB Treatment Guidelines12/08/11
THURSDAY, Dec. 8 (HealthDay News) -- New guidelines on treating
so-called "latent" tuberculosis infection in the United States
should significantly shorten and simplify the course of the therapy
from about 9 months to 3 months, according to the U.S. Centers for
Disease Control and Prevention.
The new guidelines for public health officials and health care
providers -- which are based on expert opinion and the results of
three clinical trials -- are a "game changer" for the treatment of
TB in the United States, according to CDC Director Dr. Thomas
Latent TB infection occurs when a person is infected with TB
bacteria but does not yet have symptoms and so cannot transmit the
bacteria to others. However, if the bacteria becomes active, the
person will develop the disease and can also spread it to
Certain people, including those with weakened immune systems,
are more likely to progress from latent to active TB. The CDC
notes, however, that many high-risk people with latent TB feel fine
and don't begin the nine-month course of treatment, which typically
requires 270 daily doses of the anti-TB drug isoniazid. And many of
do begin the therapy don't see it through to the end.
However, the new regimen streamlines the treatment to 12
once-per-week doses of isoniazid, along with another anti-TB drug
"This regimen has the potential to be a game-changer in the United States when it comes to fighting TB," Frieden said in a CDC news release. "It gives us a new, effective option that will reduce by two-thirds -- from nine months to three months -- the length of time someone needs to take medicine to prevent latent TB infection from progressing to active TB disease."
The new guidelines were published in the Dec. 9 issue of the
Morbidity and Mortality Weekly Report.
"If we are going to achieve our goal of TB elimination in the United States, we must ensure that those with latent TB infection receive appropriate evaluation and treatment to prevent their infection from progressing to TB disease and possibly spreading to others," Dr. Kevin Fenton, director of CDC's National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, said in the news release.
"It is critical that we accelerate progress against TB in the United States in order to avoid a resurgence of the disease," he added.
The number of people in the United States with TB remains at an
all-time low, with just over 11,000 cases reported in 2010.
However, about 4 percent of the U.S. population (11 million people)
are infected with the TB bacterium. The CDC also noted that
foreign-born people and people of color in the United States are
disproportionately affected by the illness.
These new guidelines apply only to the United States, CDC
officials said. Further research is likely needed before this
regimen could be recommended for countries with a high incidence of
TB, particularly those that have high rates of HIV and where
there's a greater risk of TB re-infection.
The American Lung Association has more about
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