Heart Failure, Diabetes Might Be Linked by
THURSDAY, Jan. 5 (HealthDay News) -- Researchers may have
pinpointed how heart disease can lead to diabetes, a finding that
could lead to new preventive treatments.
The team at Chiba University in Japan found that the stress of
heart failure activates a protein called p53, resulting in
inflammation in fat tissue, systemic insulin resistance and
worsening heart function.
This domino effect is outlined in a study in the January issue
of the journal
"Our findings clarify the reasons why the incidence of heart failure is high among diabetic patients, why the prevalence of insulin resistance is increased in heart failure patients and why treatment of insulin resistance improves the prognosis of heart failure patients," study author Tohru Minamino said in a journal news release.
Previous research by the author has shown that build-up of p53
in the heart -- from stress or age -- promotes heart failure, the
release said. While p53 is best known as a tumor suppressor, it is
also a cellular aging agent, according to Minamino. He explained
that constant activation of p53 can lead to inflammation and
Finding a way to block inflammation associated with p53
activation without compromising the protein's tumor-fighting
abilities could lead to anti-aging therapy without the cancer risk,
The U.S. National Diabetes Education Program outlines how you
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