Anthrax Vaccine Shows Promise in Monkeys01/20/12
FRIDAY, Jan. 20 (HealthDay News) -- Monkeys vaccinated with an
anthrax capsule vaccine were protected against lethal anthrax
infection, a new study has found.
The anthrax capsule is a naturally occurring component of
Bacillus anthracis, the bacterium that causes anthrax.
This is the first successful use of a non-toxin vaccine to
protect monkeys from anthrax, which is regarded as one of the most
serious bioterrorism threats, according to the U.S. Army scientists
who conducted the study.
Bacillus anthracis produces three main components that enable
it to cause harm -- lethal toxin, edema toxin and the capsule.
During anthrax infection, the capsule surrounds the bacterium and
protects it from destruction by the body's white blood cells.
In this study, the researchers found that the anthrax capsule
vaccine induced anti-capsule antibody responses in both rabbits and
monkeys. Vaccinated rabbits were not protected against anthrax
spores, but many of the vaccinated monkeys did survive.
The study appears in the Jan. 20 print issue of the journal
Current human vaccines for anthrax are based on the protective
antigen component of the anthrax toxins, but there are concerns
about relying on a single antigen and about anthrax strains that
may be vaccine resistant, said senior author Arthur Friedlander of
the U.S. Army Medical Research Institute of Infectious Diseases
"This is the first non-toxin anthrax vaccine shown to be protective in monkeys. In addition, this new capsule vaccine is expected to work against possible vaccine-resistant strains of anthrax, as well as in recipients whose immune systems may not respond to protective antigen alone," Friedlander said in a USAMRIID news release.
While the findings of the new study are promising, scientists
note that research involving animals often fails to produce similar
results in humans.
The U.S. Centers for Disease Control and Prevention has more
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