Study Finds No Link Between HPV Vaccine and Autoimmune
THURSDAY, Jan. 26 (HealthDay News) -- The human papillomavirus
(HPV) vaccine Gardasil does not trigger autoimmune disorders such
as rheumatoid arthritis, lupus, type 1 diabetes or multiple
sclerosis, according to a two-year study that included nearly
190,000 girls and women.
Gardasil is recommended in the United States for girls and young
women to protect them against HPV infection, which is the most
common sexually transmitted disease in the United States and can
lead to cervical cancer. A second HPV vaccine, GlaxoSmithKline's
Cervarix, is also approved to prevent infection with the virus.
However, long-standing concerns that the HPV vaccine might
trigger autoimmune reactions have led many parents to bar their
children from receiving the three-dose vaccine, the study authors
pointed out in a news release from Kaiser Permanente.
In the study, which was funded by Gardasil's maker, Merck &
Co., researchers analyzed the health records of almost 190,000
females aged 9 to 26 in California who were followed for six months
after receiving each dose of Gardasil in 2006-2008.
The Kaiser Permanente researchers said that, compared to females
who did not get the shot, vaccinated females did not have higher
rates of 16 autoimmune conditions, including lupus, rheumatoid
arthritis, Graves' disease, multiple sclerosis, optic neuritis and
The study, led by Chun Chao, a research scientist at the Kaiser
Permanente department of research and evaluation in Pasadena,
Calif., is published in the February issue of the
Journal of Internal Medicine.
One expert not connected with the study said the findings were
"This study confirms what we had already believed to be true of this vaccine," said Dr. Stephanie Blank, assistant professor in the department of obstetrics and gynecology and director of the gynecologic oncology fellowship at NYU Langone Medical Center in New York City. She believes that "the benefits of the HPV vaccine clearly outweigh the risks. The HPV vaccine gives us a great tool -- a means to actually prevent cervical cancer."
An expert in rheumatology agreed.
"This well-designed study looked at a large number of women who received the human papillomavirus vaccine. There did not appear to be an increased risk of developing autoimmune diseases in those vaccinated," said Dr. Harry Fischer, chief of the division of rheumatology at Beth Israel Medical Center in New York City. "This article speaks to the safety of the vaccine and helps to confirm that it does not contribute to the development of autoimmune diseases," he said.
The U.S. Centers for Disease Control and Prevention has more
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