Vitamin D May Not Boost Heart Health in Kidney
TUESDAY, Feb. 14 (HealthDay News) -- Vitamin D therapy does not
improve heart health in people with chronic kidney disease, a new
Treatment with vitamin D is primarily recommended for improving
bone health but it has been suggested for other conditions,
including cardiovascular disease. However, there is a lack of
convincing data showing that vitamin D improves cardiovascular
health, according to background information in the study.
Observational studies have reported associations between vitamin
D deficiency and increased risk of cardiovascular events in chronic
kidney disease patients, noted Dr. Ravi Thadhani, of Massachusetts
General Hospital in Boston, and colleagues.
To investigate the effects of vitamin D therapy, the researchers
conducted a clinical trial involving 227 kidney patients with mild
to moderate left ventricular hypertrophy -- a heart condition
related to enlargement of the muscle tissue in the wall of the
heart's main pumping chamber.
The vitamin D compound paricalcitol (Zemplar) was given to 115
patients while another 112 patients received an inactive
After up to 48 weeks of treatment, neither group showed
improvements on measures of cardiac structure or function. Both
groups also had similar rates of hospitalizations from any cause,
but there were fewer hospitalizations for cardiovascular
disease-related events in the vitamin D group than in the placebo
group (one versus eight, respectively).
The study, published in the Feb. 15 issue of the
Journal of the American Medical Association, was funded by Abbott Laboratories, which makes paricalcitol.
"At this time, paricalcitol cannot be recommended for patients with [chronic kidney disease]," Drs. Stefan D. Anker and Stephan von Haehling, of Charite Campus Virchow-Klinikum in Berlin, Germany, wrote in an accompanying editorial.
The American Academy of Family Physicians has more about
chronic kidney disease.
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