Findings on HIV-Resistant Sex Workers May Help Vaccine
THURSDAY, Feb. 16 (HealthDay News) -- In studying how HIV is
transmitted, researchers have discovered that some African sex
workers are naturally resistant to the virus, a finding that could
influence prevention efforts.
These women are protected by an unusually weak inflammatory
response in their vaginas, the scientists noted.
"In this part of the world, women represent over 60 percent of HIV cases, and this proportion continues to increase," Dr. Michel Roger, of the University of Montreal Hospital Centre and its microbiology and immunology department, in a news release. "Studying women who are naturally resistant to the virus enables researchers to identify interesting information in terms of developing vaccinations or microbid gels that could prevent transmission of HIV."
The researchers followed women from Benin and Zimbabwe over the
course of 15 years. They found that when some of these women are
exposed to HIV, the immune-system cells in their vaginas produced
fewer inflammatory molecules than the cells in women infected with
Although these molecules are usually helpful by activating
lymphocyte T-cells that destroy viruses, HIV actually uses these
T-cells to invade people's bodies, the researchers said.
"Fewer T-cells means fewer target cells available for the virus to use," Roger explained.
The researchers also found the women's immune response in their
vaginas -- where the virus entered their body -- was different from
their body's response once the virus was in their bloodstream. The
study concluded that a better way to stop the spread of HIV would
be to block the virus from entering the body, rather than fight it
once it had already invaded.
"AIDS vaccination research has entirely focused on the bloodstream and this approach has been a failure," Roger said. "Our research shows that the immune response is different at the site of the infection, and that we should turn to the entry points in order to find a means for blocking the virus."
The researchers said that the body's mucus membranes would be
protected through a through a nasal-spray vaccine.
They added that more research is needed to fully understand the
immune response in the vagina and determine if women's DNA plays a
role in natural HIV resistance.
The results were recently published in the journal
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