Gastrointestinal Tumor Patients Live Longer on Cancer
WEDNESDAY, March 28 (HealthDay News) -- Extended treatment with
the cancer drug Gleevec leads to improved survival rates in
patients who have had surgery to remove a gastrointestinal stromal
tumor and have a high risk of cancer recurrence, a new study
"Gastrointestinal stromal tumors are usually found in the stomach or the small intestine but can occur at any site along the gastrointestinal tract and rarely elsewhere within the abdominal cavity," according to background information in the study by Finnish researchers.
Treatment with Gleevec (imatinib) for a year after surgery has
improved recurrence-free survival in patients, but disease
recurrence is common during the first year after imatinib treatment
stops, suggesting that one year of treatment may not be long
The study compared outcomes among 200 patients who received 400
milligrams (mg) of imatinib per day for 12 months and 200 patients
who received the same amount of medication for 36 months. The
patients, all of whom were from Finland, Germany, Norway or Sweden,
began taking imatinib within 12 weeks after surgery.
Rates of recurrence-free survival after five years were
approximately 66 percent in the 36-month group and 48 percent in
the 12-month group. Rates of overall survival after five years were
92 percent in the 36-month group and 82 percent in the 12-month
Patients in the 36-month group were more likely to stop taking
imatinib than those in the 12-month group -- 26 percent compared to
13 percent. The reasons included patient preference and adverse
side effects. Nearly all the patients in the study had at least one
adverse side effect, most of which were considered mild.
The study appears in the March 28 issue of the
Journal of the American Medical Association.
The American Cancer Society has more about
gastrointestinal stromal tumors.
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