Crouse Health Online: Wellness is just a click away.
Share Share
  |  Connect with Us: 
large
med
small
Text Size
 

Health News



Research Gets Closer to Genetic Roots of Glaucoma

Research Gets Closer to Genetic Roots of Glaucoma

04/27/12

FRIDAY, April 27 (HealthDay News) -- Two genetic variations are linked to a common form of glaucoma, known as primary open-angle glaucoma, according to new research.

Glaucoma affects about 2.2 million people in the United States, the U.S. National Eye Institute said in a news release.

"Loss of vision from glaucoma, a common cause of blindness worldwide, is due to irreversible damage to the optic nerve," noted one expert, Dr. Mark Fromer, an ophthalmologist at Lenox Hill Hospital in New York City. "Glaucoma is usually associated with high eye pressure leading to optic nerve damage. There is also a form of glaucoma with normal pressure."

In the new study, Janey Wiggs, of Harvard Medical School and Massachusetts Eye and Ear Infirmary in Boston, and colleagues analyzed the DNA sequences of more than 6,000 people. Half of them had primary open-angle glaucoma. This form of the disease is typically associated with increased eye pressure, but one-third of these patients had normal-pressure glaucoma.

The study, published online April 26 in PLoS Genetics, found that two genetic variations were linked with primary open-angle glaucoma, including those who have normal-pressure glaucoma.

One variant is in a gene located on chromosome 9. The second variant is in a region of chromosome 8, where it may affect the expression of one or two other genes. These genes may interact with a molecule that regulates cell growth and survival throughout the body, the researchers explained in the news release.

The investigators believe future studies could focus on this molecule as a treatment for various forms of glaucoma.

Fromer concurred. "These results reveal new insights into the genetic pathways of optic nerve disease in glaucoma for the first time and are an important step toward the development of preventative and protective therapies," he said.

More information

The U.S. National Library of Medicine has more about glaucoma.

Copyright © 2012 HealthDay. All rights reserved.

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

OF INTEREST:
 

Latest News

Crouse Hospital Appoints Chief Information Officer
more >

MedEx Bedside Prescription Delivery Service

Free service offers convenience, patient education at discharge.
more >

Weight Loss Surgery

Is it right for you? Attend a free information seminar held twice monthly.
more >

Quality at Crouse

See how Crouse Hospital strives to provide the best in patient care.
more >

Cheer Up That Special Someone

Say get well or welcome a new arrival with a gift purchased right at Crouse.

more >

Make an Online Donation Now

Your donation of any amount helps support Crouse services & programs in a meaningful way.
more >

Shop Online Now

Say get well, thinking of you or welcome new baby with a unique gift from the Crouse Gift Shop.

more >