Breast-Feeding Might Cut Risk for Tough-to-Treat Breast Cancer: Study10/18/12
THURSDAY, Oct. 18 (HealthDay News) -- Breast-feeding may reduce
a woman's risk for a form of breast cancer that's particularly
difficult to treat, a new study suggests.
The study, by researchers at Columbia University, found that
breast-feeding lowered the odds for estrogen receptor-negative and
progesterone receptor-negative (ER/PR-) breast cancer.
These types of tumors have cells that do not carry a protein on
their surface that binds to the hormones estrogen or progesterone.
This means that they cannot be treated with standard hormone-based
Since there are few modifiable factors for ER/PR-negative breast
cancers, the researchers concluded that women at risk for this type
of tumor should be encouraged to breast-feed.
The study is scheduled to be presented Thursday at the annual
cancer prevention conference of the American Association for Cancer
Research (AACR) in Anaheim, Calif.
"We found an increased risk for estrogen receptor- and progesterone receptor-negative breast cancer in women who do not breast-feed, but in women who have children and breast-feed, there is no increased risk," study co-author Meghan Work, a doctoral student in the department of epidemiology at Columbia's Mailman School of Public Health in New York City, said in an AACR news release.
Still, one expert said the findings must be interpreted with
"This was an observational study, and a causal relationship between breast-feeding and the decreased incidence of hormone-negative breast cancer is not established," stressed Dr. Alyssa Gillego, from the department of breast surgical oncology at Beth Israel Comprehensive Cancer Center, in New York City.
The study involved more than 4,000 women with breast cancer and
almost 3,000 women without cancer. The researchers used data from
the Breast Cancer Family Registry to examine the link between
ER/PR-negative breast cancer and women's reproductive risk factors,
such as the number of children they delivered and whether or not
they breast-fed or took oral contraceptives.
The study found that having three or more children but not
breast-feeding was linked to an increased risk ER/PR-negative
"Women who had children but did not breast-feed had about 1.5 times the risk for ER/PR-negative breast cancer when compared with a control population. If women breast-fed their children, there was no increased risk for ER/PR-negative cancer," Work noted. "This is particularly important as breast-feeding is a modifiable factor that can be promoted and supported through health policy."
They study also revealed that use of oral contraceptives made
after 1975 was not associated with an increased risk for
ER/PR-negative cancer risk.
Another specialist added, however, that there is a plausible
explanation for a connection between breast-feeding and
"Obviously, the breasts are meant to serve as an organ that produces milk for a newborn," explained Dr. Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital, in New York City. "Breasts are in an immature state until one's first pregnancy. Theoretically, if left in the immature state, breasts are not developing in the manner that nature intended. This altering of what nature intended may be the reason why women that do not breast-feed have a higher rate of cancer."
There could be other factors, she added. "The lowered risk might
also be due to exposure or withdrawal of hormones as one nurses an
infant," Bernik reasoned. "More study needs to be directed to
finding out why nursing is protective, as this might lead to new
methods of preventing breast cancer development."
Findings presented at medical meetings are typically considered
preliminary until published in a peer-reviewed journal.
The U.S. National Institutes of Health has more about
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