Heavy Smoking May Raise Odds for Lethal Bladder Cancer01/14/13
MONDAY, Jan. 14 (HealthDay News) -- Heavy smokers are more
likely to develop aggressive and deadly bladder cancers than those
who smoke less or nonsmokers, new research shows.
Smoking is one of the most common causes of bladder cancer, but
it hasn't been known how it affects the progress of the
In this study, researchers looked at data from 212 bladder
cancer patients in Los Angeles County, in California. Patients who
were heavier smokers were more likely to have deadly bladder cancer
than those who were lighter smokers or those who never smoked.
The study also identified changes in certain proteins that are
often present in lethal bladder cancer. Patients with changes in
six to nine proteins fared badly, which suggests that they could
have benefited from more aggressive treatment.
The greater the number of changes in these proteins, the worse a
patient's outcome, according to the study published online Jan. 14
in the journal
Although the study tied heavier smoking to higher death risk
from bladder cancer, it did not establish a cause-and-effect
The findings are important because bladder cancer is one of the
most expensive types of cancer to treat, study co-author Dr.
Richard Cote, of the University of Miami Miller School of Medicine,
said in a journal news release.
He said treatment tailored to individual bladder cancer patients
is "urgently needed."
The U.S. National Cancer Institute has more about
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