Crouse Health Online: Wellness is just a click away.
Share Share
  |  Connect with Us: 
large
med
small
Text Size
 

Health News



Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters

Estrogen Level in Pregnancy May Affect Breast Cancer Risk in Daughters

04/09/13

TUESDAY, April 9 (HealthDay News) -- Daughters born to women who had excess levels of estrogen during pregnancy may be at increased risk for breast cancer, a new study suggests.

That's because high estrogen levels in the womb can disable the powerful breast cancer tumor suppressor gene BRCA1 in daughters, the researchers at Georgetown Lombardi Comprehensive Cancer Center said in a Georgetown news release.

Their study of 1-year-old girls whose mothers had high estrogen levels during pregnancy also found that the daughters had other gene abnormalities that can contribute to the risk of breast cancer and breast cancer recurrence.

This includes a gene defect in the so-called unfolded protein response pathway, which has been linked to breast cancer risk and resistance to the breast cancer drug tamoxifen.

Although the study found an association between high estrogen levels in pregnancy and factors that raise breast cancer risk in daughters, it did not prove cause and effect.

If the findings are confirmed, they could be used to identify women at increased risk for breast cancer and to lower their risk before the disease develops, the researchers said.

There are drugs available that may make it "possible to reverse the increase in breast cancer risk and prevent development of resistance to tamoxifen in these women," study lead author Leena Hilakivi-Clarke, a professor of oncology at Georgetown Lombardi, said in the news release.

The study was to be presented Tuesday at the American Association for Cancer Research annual meeting, in Washington, D.C. The data and conclusions of research presented at meetings are typically considered preliminary until published in a peer-reviewed medical journal.

More information

Breastcancer.org has more about breast cancer risk.

Health News Copyright © 2013 HealthDay. All rights reserved.

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

OF INTEREST:
 

Latest News

Crouse Hospital First in Region to Use New da Vinci Xi Surgical System
more >

MedEx Bedside Prescription Delivery Service

Free service offers convenience, patient education at discharge.
more >

CrouseSports Express After-Hours Ortho Care

Immediate care of orthopedic injuries in kids and adults.
more >

Weight Loss Surgery

Is it right for you? Attend a free information seminar held twice monthly.
more >

Quality at Crouse

See how Crouse Hospital strives to provide the best in patient care.
more >

Cheer Up That Special Someone

Say get well or welcome a new arrival with a gift purchased right at Crouse.

more >

Make an Online Donation Now

Your donation of any amount helps support Crouse services & programs in a meaningful way.
more >

Shop Online Now

Say get well, thinking of you or welcome new baby with a unique gift from the Crouse Gift Shop.

more >