Pets Battling Cancer Can Join Clinical Trials Too06/14/13
THURSDAY, June 13 (HealthDay News) -- If you hear that a
friend's beloved family member has joined a clinical trial for
cancer treatment, don't assume the patient is human.
Cancer is the leading cause of death in older dogs and cats, and
clinical trials offer hope that effective medications will be
developed -- for humans and their four-legged friends, cancer
The new National Veterinary Cancer Registry, launched last month
by a national team of animal and human cancer doctors, will point
pet owners toward clinical trials that might benefit their beloved
companions and speed up the development of life-saving therapies
"We will be able to decrease the cost and beat the time involved in drug discovery," said the registry's founder, Dr. Theresa Fossum, a professor of surgery at Texas A&M University's college of veterinary medicine.
Because many similar diseases affect people and their animals,
veterinarians and physicians say a lot can be learned from studying
how treatments work in cats and dogs.
The drug-assessment process could be accelerated by a simple
fact: dogs age many times faster than humans, and their cancers
progress more rapidly too. Also, many canine and feline cancers --
including sarcoma; non-Hodgkin lymphoma; leukemia; mesothelioma;
and bone, ovarian, kidney, uterine and oral cancers -- are
virtually the same cancers humans have.
Experts not involved with the registry said the concept of the
database looks promising.
"These clinical trials would be more real-world than a lab experiment," said Dr. Peter Rabinowitz, associate professor of medicine at Yale School of Medicine and head of the Yale Human Animal Medicine Project, which studies clinical connections between human and animal medicine.
Dogs often are an interesting model for better understanding
environmentally induced cancers, Rabinowitz said. "Asbestos causes
cancer in humans 35 years [after exposure], but if you're a dog,
you get it in four to five years, so we can see how the cancers
develop more naturally," he said.
Fossum said she has always been bothered by the slow and
cumbersome way drugs are tested. "If it's a cancer drug, they're
going to put a human tumor in a mouse ... but it's not very
predictive of how drugs will work in people," she said.
Then, after tests to see if the drugs might be toxic in humans,
the drugs are evaluated in human clinical trials, which take more
than a decade to conduct. "So the drugs that are coming out now
were starting [to be evaluated] 12 years ago," she said.
Testing the drugs in pets speeds up the process, allowing
researchers to determine if a medication works before taking it to
human clinical trials, Fossum said. With a pet owner's informed
consent, "we can try a new drug that seems promising a lot sooner,"
The concept of a cancer database for dogs and cats could expand
to include other diseases, such as diabetes. About 800,000 dogs
have type 1 diabetes in the United States, Fossum said. Other
conditions that a veterinary registry could serve include
endocrine, neurological and cardiac issues.
About 6 million dogs and 6 million cats in the United States
receive a cancer diagnosis each year, according to the Animal
Cancer Foundation, in Norwalk, Conn. If your dog or cat is one of
them, you can register your pet with the National Veterinary Cancer
The registry was created by a consortium of animal and human
cancer doctors, including specialists from the Baylor Healthcare
System in Texas, the Texas Veterinary Oncology Group and the CARE
Foundation, a Florida-based animal rescue and wildlife education
Because the registry is new, it may take some time before
effective clinical trial matchmaking can occur between animals and
drug developers, Fossum said.
Learn more about the connection between animal and human health
for Disease Control and Prevention.
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