Sense of Smell Determined by Genes, Study Says08/02/13
FRIDAY, Aug. 2 (HealthDay News) -- Genetic differences appear to
explain why some people can smell certain odors and others can't,
Using 10 different odors, the researchers tested nearly 200
people for their smell sensitivity and then analyzed the
participants' DNA. For four of the odors tested, there was a link
between smell sensitivity and certain genetic variants.
The four odors are malt, apple, blue cheese and violets,
according to the findings, published online Aug. 1 in the journal
"We were surprised how many odors had genes associated with them. If this extends to other odors, then we might expect everyone to have their own unique set of smells that they are sensitive to," research team co-leader Jeremy McRae, of Plant and Food Research in New Zealand, said in a journal news release.
"These smells are found in foods and drinks that people encounter every day, such as tomatoes and apples. This might mean that when people sit down to eat a meal, they each experience it in their own personalized way," McRae said.
He and his colleagues also found that people's ability to smell
these four odors was the same worldwide. That means that someone in
Asia is just as likely to be able to smell one of the odors as
someone in Africa or Europe.
The ability to smell one of these odors doesn't predict the
ability to smell the others, the study also found. So if someone is
good at smelling blue cheese, it doesn't mean they'll be good at
smelling an apple next to it.
The genetic variants that affect the ability to smell these four
odors are in or near genes that encode odorant receptors. The
researchers explained that odor receptor molecules sit on the
surface of sensory nerve cells in the nose. When certain chemical
compounds float in the air, the nerve cells send a signal to the
brain and give you the perception of a smell.
Richard Newcomb, co-leader of the project, said that knowing the
compounds that people can sense in foods, as well as other
products, will influence the development of future products.
"Companies may wish to design foods that better target people based
on their sensitivity, essentially developing foods and other
products personalized for their taste and smell," he said in the
The U.S. National Institute on Deafness and Other Communication
Disorders has more about
smell and smell disorders.
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