Gel May Offer Simple Treatment for Newborns With Low Blood Sugar09/26/13
THURSDAY, Sept. 26 (HealthDay News) -- An easy-to-use gel
containing dextrose -- a form of sugar -- may be an effective way
to treat low blood sugar levels in newborns, new research
Giving infants two doses of the gel nearly halved the odds of
treatment failure for low blood sugar, or hypoglycemia, compared to
an inactive placebo, according to study author Jane Harding, at the
University of Auckland in New Zealand, and colleagues.
"Dextrose gel should be considered for first-line treatment to manage hypoglycemia in late preterm and term babies in the first 48 hours after birth," the researchers concluded in the study published online Sept. 25 in The Lancet.
Low blood sugar levels (hypoglycemia) can be a serious problem
in newborns. It's associated with brain injury and poor
neurodevelopmental outcomes, according to study background
information. Between 5 percent and 15 percent of newborns may have
The incidence of hypoglycemia appears to be on the rise, the
researchers noted. And, they suspect that the increase in maternal
obesity and diabetes may be part of the reason.
Dr. Deborah Campbell, director of the division of neonatology at
the Children's Hospital at Montefiore in New York City, said three
main reasons explain why certain groups of babies may be
hypoglycemic soon after birth.
For babies born to mothers with diabetes, especially
uncontrolled diabetes, the mother's high blood sugar levels cause
the baby's body to pump out more insulin -- a hormone that helps
lower blood sugar -- in response. After birth, all the extra
insulin can make the baby's blood sugar levels drop. Because the
baby may have been living in a high-blood sugar environment, their
bodies may not compensate as well as they otherwise might have,
The second group at risk includes babies who are premature and
growth-restricted, known as small for gestational age. "These
babies don't have significant stores of glycogen (a natural form of
sugar in the body). They have lower glycogen stores and less
nutrients available, so they very quickly deplete what they have in
terms of stored glycogen. But, within 24 hours or so, they can
usually stabilize," Campbell noted.
The third group is sick babies, because the stress of illness
can speed up the metabolism as the body tries to deal with the
For the current study, the researchers randomly assigned 237
babies who had hypoglycemia to receive either treatment with a 40
percent dextrose gel placed between the cheeks and gums or a
placebo. The dextrose dose was based on the baby's body weight. The
babies received up to six doses over 48 hours.
All of the babies were born at a single center in New Zealand
between 2008 and 2010, at 35 weeks' gestation or higher.
Just 14 percent of babies on the gel experienced treatment
failure -- a low blood sugar level after two doses -- while 24
percent of the placebo group had treatment failure. Babies given
the gel were less likely to be admitted to intensive care for
hypoglycemia, and less likely to be given supplemental formula
The study authors estimate this intervention would cost about $2
"In a resource-poor environment, this is an outstanding tool," said Dr. Richard Schanler, director of neonatal services at North Shore-LIJ Health System in New Hyde Park, N.Y. He was not involved with the study.
However, both he and Campbell were unsure if such a treatment
would catch on in the United States. Schanler said that currently,
if a baby is hypoglycemic, the baby is given a feeding -- either
breast or formula -- to raise the blood sugar. Blood sugar is then
checked again at 30 minutes, and if it's still low, the baby is
given another feeding. If blood sugar levels don't rise, a baby may
need intravenous glucose and that type of care generally occurs in
a neonatal intensive care unit (NICU), he explained.
But, he added, "A little bit of feeding is usually enough to get
the blood sugar to rise."
Schanler said his biggest concern with not sending a baby with
sustained hypoglycemia to the NICU is that it might be harder to
quickly identify a baby with an underlying abnormality or
"On the one hand it seems like a great, inexpensive idea, but it would have to be adopted with caution and additional training of personnel," Schanler said.
"This is something to be thoughtful about," Montefiore's Campbell noted, "but it definitely needs more study. But, if you can find something that works as well as IV glucose for kids who are otherwise healthy and born over 35 weeks' gestation, it could save a lot of money," she added.
"But, dextrose gel doesn't work for every baby. We would need to dissect the findings of this and other studies to find out which babies would benefit most," Campbell said.
Learn more about gestational diabetes, which can lead to low
blood sugar in babies, from the
American Diabetes Association.
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