HPV Vaccines May Be Less Effective for Black Women: Study10/28/13
MONDAY, Oct. 28 (HealthDay News) -- Black women may get less
protection than whites from the vaccines recommended for preventing
human papillomavirus (HPV), which causes cervical cancer, a new
The currently available vaccines, Gardasil and Cervarix, don't
target the types of HPV infection found most often in black women,
the study authors said.
Experts have long believed that most cervical cancers are caused
by persistent infection with subtypes of the sexually transmitted
virus known as HPV 16 and HPV 18. These are the strains targeted by
Gardasil and Cervarix. (Gardasil also targets HPV 6 and HPV
But black women tend to develop cancer of the cervix -- the
lower part of the uterus or womb -- and die from it more often than
white women, even when screening programs are similar, according to
background information included in the study. This led the
researchers to wonder if blacks might be less likely to benefit
"HPV 16 and 18 occur less frequently in African-Americans than in whites," said study researcher Cathrine Hoyo, associate professor of obstetrics and gynecology at the Duke University School of Medicine.
Hoyo's team looked at women who had abnormal results on Pap
tests -- screenings to detect precancerous cervical
Of the nearly 600 women with Pap smear abnormalities in the
study, about 86 percent had detectable HPV, Hoyo said.
"African-Americans had half the HPV 16 and 18 frequency as whites did," said Hoyo, who is scheduled to present the findings Monday at a conference of the American Association for Cancer Research in National Harbor, Md.
The findings, if replicated in larger studies, could call into
question the effectiveness of the current vaccines for all races,
But women should still get an HPV vaccine, said Dr. Robert
Morgan, co-director of the gynecological oncology program at the
City of Hope Comprehensive Cancer Center in Duarte, Calif. "I don't
think recommendations on vaccination would change [based] on this
data," said Morgan, who was not involved in the research.
The American Cancer Society estimates that more than 12,000 new
cases of cervical cancer will be diagnosed this year, and more than
4,000 women will die of the disease. Blacks are about 20 percent
more likely to get cervical cancer, Hoyo said, and about twice as
likely to die from it as white women.
The U.S. Centers for Disease Control and Prevention recommends
HPV vaccination for preteen boys and girls at age 11 or 12, before
sexual activity begins. The vaccines, given in three injections
over a six-month period, cost about $400 or more total.
In developing Gardasil and Cervarix, scientists relied on
studies to pinpoint the strains of HPV most likely to lead to
cancer. Studies were done on all ethnicities, Hoyo said, noting
that there may have been insufficient numbers of black women in the
research studies to pick up the differences in HPV subtypes.
"There has always been some skepticism about whether there are other strains that are important, other than 16 and 18," she said. This study is not the first to report the differences, she said.
The findings, however, are not a reason for blacks not to get an
HPV vaccine, Hoyo said. Testing of vaccines that target additional
HPV subtypes are under way, and in time the problem may be solved,
Research presented at medical meetings should be viewed as
preliminary until published in a peer-reviewed journal.
To learn more about cervical cancer, visit the
American Cancer Society.
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