Crouse Health Online: Wellness is just a click away.
Share Share
  |  Connect with Us: 
large
med
small
Text Size
 

Health News



Study of Severely Obese Family Leads to Gene Discovery

Study of Severely Obese Family Leads to Gene Discovery

11/21/13

THURSDAY, Nov. 21, 2013 (HealthDay News) -- Researchers report that they have identified a gene that is tied to severe obesity.

They say their findings could lead to new treatments for obesity.

The team studied an Israeli Arab family whose members were severely obese. They found that the family members had a mutation in a gene that produces a protein called CEP19.

When the researchers deleted this gene in mice, the rodents became obese and developed diabetes. They also had increased appetites and burned less energy.

Scientists note, however, that research done in animals often fails to produce similar results in humans.

The study was published online Nov. 21 in the American Journal of Human Genetics.

"Starting with gene discovery in a single family with morbid obesity, these studies led to the identification of a gene that seems to be fundamental to regulating nutritional status [body weight]," study co-senior author Dr. John Martignetti, of the Icahn School of Medicine at Mount Sinai, in New York City, said in a journal news release.

"This gene is shown to be present not only in humans and mice, but also in the simplest known single-cell animal," he said. "Nature considers this gene so important that it has preserved its structure for more than 700 million years."

The specific role of the CEP19 protein in maintaining a balance between leanness and obesity remains unknown. Further research is needed to determine how the protein affects appetite control, the amount of calories the body burns and insulin sensitivity, the study authors said.

Previous research has indicated that genes play a role in 40 percent to 90 percent of cases of obesity, according to the news release.

More information

The U.S. National Heart, Lung, and Blood Institute has more about overweight and obesity.

Copyright © 2013 HealthDay. All rights reserved.

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

OF INTEREST:
 

Latest News

Crouse Hospital Appoints Chief Information Officer
more >

MedEx Bedside Prescription Delivery Service

Free service offers convenience, patient education at discharge.
more >

CrouseSports Express After-Hours Ortho Care

Immediate care of orthopedic injuries in kids and adults.
more >

Weight Loss Surgery

Is it right for you? Attend a free information seminar held twice monthly.
more >

Quality at Crouse

See how Crouse Hospital strives to provide the best in patient care.
more >

Cheer Up That Special Someone

Say get well or welcome a new arrival with a gift purchased right at Crouse.

more >

Make an Online Donation Now

Your donation of any amount helps support Crouse services & programs in a meaningful way.
more >

Shop Online Now

Say get well, thinking of you or welcome new baby with a unique gift from the Crouse Gift Shop.

more >