Baldness Cure May Have Inched a Bit Closer01/28/14
TUESDAY, Jan. 28, 2014 (HealthDay News) -- Scientists might be
able to offer "hair-challenged" males a new glimmer of hope when it
comes to reversing baldness.
Researchers from the University of Pennsylvania say they've
gotten closer to being able to use stem cells to treat thinning
hair -- at least in mice.
The researchers said that although using stem cells to
regenerate missing or dying hair follicles is considered a
potential way to reverse hair loss, it hasn't been possible to
create adequate numbers of hair-follicle-generating stem cells --
specifically cells of the epithelium, the name for tissues covering
the surface of the body.
But new findings indicate that this may now be achievable.
"This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles," Dr. Xiaowei Xu, an associate professor of dermatology at Penn's Perelman School of Medicine, said in a university news release.
Those cells have many potential applications that extend to
wound healing, cosmetics and hair regeneration, Xu said.
In the new study, Xu's team converted induced pluripotent stem
cells (iPSCs) -- reprogrammed adult stem cells with many of the
characteristics of embryonic stem cells -- into epithelial stem
cells. This is the first time this has been done in either mice or
people, the researchers said.
The epithelial stem cells were mixed with certain other cells
and implanted into mice. They produced the outermost layers of skin
cells and follicles that are similar to human hair follicles,
according to the study, which was published Jan. 28 in the journal
Nature Communications. This suggests that these cells might
eventually help regenerate hair in people, the researchers
Xu said this achievement with iPSC-derived epithelial stem cells
does not mean that a treatment for baldness is around the corner. A
hair follicle contains both epithelial cells and a second type of
adult stem cell called dermal papillae.
"When a person loses hair, they lose both types of cells," Xu said. "We have solved one major problem -- the epithelial component of the hair follicle. We need to figure out a way to also make new dermal papillae cells, and no one has figured that part out yet."
Experts also note that studies conducted in animals often fail
when tested in humans.
The American Academy of Dermatology has more about
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